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However, this limitation reflects reallife clinical scenarios in which the perimenopause transition is variably experienced by patients and documented by clinicians

During the randomized treatment period, patients received a standard lifestyle instruction every 12 weeks on reduced-calorie diet (approximately 500 kcal/day deficit) and increased physical activity (recommended minimum of 150 min/week) that began with the first dose of ZEPBOUND or placebo and continued throughout the 72-week treatment period

The gradual dose escalation schedule recommended in the FDA label (starting at 2.5 mg weekly and increasing every 4 weeks) allows for physiological adaptation

Note: Mounjaro is not FDA-approved to treat obesity or for weight loss

A Bioequivalence Study of Two Formulations of Oral Semaglutide in Healthy Participants