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Long-term GLP-1 use also means that nutritional needs evolve over time

However, you might notice the effect of lower hunger wearing off after 4-5 days post-injection in the first month of taking Wegovy

Emergence of highly effective GLP-1 agonists, such as Novos semaglutide (Ozempic, Wegovy, and Rybelsus) and liraglutide (Saxenda), and Lillys tirzepatide (Mounjaro) has completely transformed the market for weight loss and diabetes 2

Supply shortages are one of the big hurdles for companies in the market, as spiking demand has made it difficult for many patients to access the treatments

GLP-1 also seem to act on the reward and satiety centers of the brain (more research is being done on exactly what mechanisms)