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What is the mechanism driving the reduction of cardiovascular events from glucagon-like peptide-1 receptor agonists?-A mini review

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To clarify the involved signalling pathways, cells were incubated with AICAR (0.5 mmol/L), compound C (10 mol/L), exendin (939) (200 nmol/L) or H89 (10 mol/L) for 30 min before other treatments

( 10.1016/j.jacbts.2022.08.002) [DOI] [PMC free article] [PubMed] [Google Scholar] Pyke C Heller RS Kirk RK Orskov C Reedtz-Runge S Kaastrup P Hvelplund A Bardram L Calatayud D & Knudsen LB

The theory is that they might pull down overall inflammation and thus help with RA activity