retatrutide triple agonist glp-1 gip glucagon phase 2 nejm 2023 for Obesity: Weight-Loss Data The evolution of obesity medicines
Description
The ADJUNCT ONE trial found that symptomatic hypoglycemia had a dose-related effect with a rate ratio between 1.27 and 1.31 on doses of 1.2 and 1.8 mg of liraglutide, respectively
These side effects can persist for as long as you take the medication
[PubMed ID: 15555420]
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The figure below is from Pratley2018
With significant caloric restriction, studies show the body may reduce conversion of thyroid hormone T4 to the more active T3 form and alter sympathetic nervous system activity, both of which can influence heat production
