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Chronic pain, fatigue, medication side effects, and disease-related stress contribute to the increased risk of mental health disorders in this population

Lifestyle and behavioral interventions aimed at reducing calorie intake and increasing energy expenditure have limited effects because complex and lasting hormonal, metabolic and neurochemical adaptations can prevent weight loss and promote weight recovery (8)

While semaglutide is highly effective but expensive, orlistat provides a more affordable option

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When GLP-1 Therapy May Be Appropriate After Weight Loss Surgery Many patients reach a weight loss plateau 18-24 months after bariatric surgery, when the initial rapid weight loss slows and appetite naturally returns