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The key rule is maintaining minimum spacing between doses: Semaglutide: minimum 48 hours (2 days) between doses when shifting injection day Tirzepatide: minimum 72 hours (3 days) between doses when shifting injection day Retatrutide: follow your research protocol spacing, typically weekly If you fly east (losing hours), your injection day arrives sooner than expected

This was based on the one study which failed to find residual gastric contents when patients performed a 24 hour fast from solid food and a 12 hour fast from liquids

Potential Risks During Anaesthesia The main concern with GLP-1 receptor agonists during surgery relates to their effect on gastric emptying

CYP-mediated metabolism plays a central role in many CNS interactions

No trial date has been set, but the science day laid important groundwork for future proceedings