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In this study, just over 700 symptomatic patients with HFpEF (LVEF 50%) and BMI 30 kg/m 2 were randomised to weekly tirzepatide or placebo and followed for a median of ~2 years

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Systemic hypertension has been linked to the development of obesity-related CKD 26 , but we observed a direct relationship between decreases in systolic BP and decreases in eGFR at multiple time points