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However, both medications can affect kidney function indirectlymetformin requires renal clearance and should be dose-adjusted or discontinued if eGFR falls below 30 mL/min/1.73m, while GLP-1 agonists can cause volume depletion through weight loss and reduced appetite, potentially stressing kidneys in individuals with baseline renal impairment

A.le RouxC

Slowing down digestion, and reducing appetite

This can lead to stress around eating times or overthinking meals, particularly during busy or unpredictable days

It has been also postulated that there is interindividual variation in the susceptibility of the metabolic organs (e.g., liver, pancreas) to visceral adiposity (liposusceptibility) and this contributes to the manifestation of insulin resistance and adverse effect of excess fat at variable body mass index (BMI), and in different ethnic groups [17]