goodrx glp-1 novo nordisk partnership Announces Collaboration with to Expand Access to Ozempic® and Wegovy® for $499-Per-Month GoodRx CEO discusses Novo Nordisk

Tirzepatide (the active ingredient in Mounjaro and Zepbound) acts on both GLP-1 and GIP receptors simultaneously

It has been licensed worldwide for the treatment of type 2 diabetes mellitus in adult patients, including in the United States and Europe

These tend to resolve with continued use or dose adjustment

According to NICE guidance and MHRA safety information, healthcare professionals should maintain vigilance for rare but serious adverse effects including acute pancreatitis, gallbladder disease, and potential thyroid tumours (based on animal studies, though human risk remains uncertain)

HPG axis central effects: hypothalamus and pituitary Evidence on the potential neuroendocrine actions of GLP-1 on HPG axis was provided by an in vitro study in a rodent hypothalamic neuronal cell line (GT1-7) that reported a dose-dependent stimulating effect of GLP-1 on GnRH release, in association with a prompt increase in the plasma LH levels following the intracerebroventricular injection of GLP-1 in male rats [34]