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The use of human GIP in rodent studies may, hence, even under supraphysiological doses, not yield sufficient occupancy and/or downstream signaling at the brain GIPR to affect feeding

GLP-1 Signaling Pathway Glucagon-like peptide-1 (GLP-1) exerts its physiological effects by binding to the GLP-1 receptor (GLP-1R), a class B1 G-protein-coupled receptor (GPCR)

Their actions in different tissues are described below

You might know them better by their brand names: Ozempic, Wegovy and Mounjaro