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glp 1 drugs and addiction IUPHAR review – Glucagon-like peptide-1 (GLP-1) substance use disorders: An emerging pharmacotherapeutic target Prospects of GLP-1 Therapies for
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doi: 10.1210/endo.142.5.8128

BMJ 381 , e073312 (2023)

Hamano T, Enomoto S, Shirafuji N, Ikawa M, Yamamura O, Yen SH, et al

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The importance of W33 in small-molecule activation of GLP-1R was curious since it is located on the extracellular domain (ECD), distal from the transmembrane domains and connecting loops directly involved in peptide-induced GPCR activation ( 20, 32 )
