veracity glp 1 GLP-1 Daily Support – 21st

Is medication enough, or do I still need to focus on diet and exercise

1).29,32 With respect to the vascular system, rGLP-1 activation induces modest decreases in blood pressure,33,34 it has a vasodilator effect, improves arterial stiffness, and prevents atherosclerotic plaque formation-and has plaque stabilizing effects-through its anti-inflammatory and antiapoptotic effects as demonstrated in animal models.29,32,3538 Despite controversies about rGLP-1 expression in vascular smooth muscle and endothelial cells, studies have shown that arGLP-1 has antiproliferative effects on these cells,39 reduces oxidative stress, improves endothelial function, and increases nitric oxide production in experimental models.3540 In the heart they produce a discrete increase in heart rate (24 beats/min), although this does not seem to be associated with an increase in arrhythmias or cardiovascular events

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FDA has approved dipeptidyl peptidase-4 (DPP-IV) resistant long-acting GLP-1s as injectable drugs for treating patients with type 2 diabetes

After 8 weeks of follow-up, the administration of lixisenatide increased the phosphorylation of NHE3, which reduced its activity in urinary extracellular vesicles in comparison to once-daily insulin glulisine treatment (Tonneijck et al., 2019)