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Diabetes Med (2003) 20(6):5067

2005 doi: 10.1111/j.1365-2249.2005.02934.x

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However, based also on small histopathologic studies that pointed to a marked expansion of the exocrine and endocrine pancreatic compartments with the use of incretin-based therapies, the former being accompanied by increased proliferation and dysplasia and the latter by -cell hyperplasia with the potential for evolution into neuroendocrine tumors [105], concerns remain [106], and monitoring for and reporting of pancreatic adverse effects will continue [104]

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