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2022;61(3):e1124

Semaglutide, a glucagon-like peptiede-1 (GLP-1) receptor agonist, was approved by the Food and Drug Administration (FDA) to treat diabetes in 2017 and for weight loss in 2021 [3]

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Therefore, it is possible that preservation of TCF7L2 expression could lead to reduce the atherosclerosis through the increase of GLP-1 receptor expression and decrease of inflammation process, although further evaluation would be necessary to demonstrate this point