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2) Of the weight lost, what proportion came from lean or muscle-related compartments

GLP-1 promotes its biological action through binding to the GLP-1 receptor (GLP-1R), a 7 transmembrane G protein-coupled receptor of the class B family (41)

But Tom Wadden, a psychology professor at the University of Pennsylvanias Perelman School of Medicine, said he is not concerned that semaglutide could cause similar issues

Fatigue or asthenia is recognised as a common adverse reaction for some GLP-1 receptor agonists, as documented in their Summary of Product Characteristics (SmPCs)

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