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In conditions such as Alzheimers disease (AD), Parkinsons disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Huntingtons disease (HD), and Lewy body dementia (LBD), dysregulated glial activity, marked by sustained microglial and astrocytic activation, initiates a cascade of cytokine release, oxidative stress, and impaired neuronal support

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Retatrutide may deliver greater weight loss than existing drugs by acting on three hormones, but risks like side effects, muscle loss, and emotional changes remain concerns.

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