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Summary SGLT2-i exert more consistent BP-lowering effects than GLP-1RA, largely due to their diuretic-like action

Studies on metabolic rate after GLP-1 medication discontinuation show that resting metabolic rate returns to predicted levels based on new body weight within 3-6 months

Thus, for a number of them, even if they are good substrates in vitro , other clearance pathways may be more important in vivo or, if they are cleaved by DPP-4, removal of the N-terminal dipeptide may have no effect upon their biological activity
Zhou, R., Yazdi, A

Monitoring during the transition If you have diabetes or prediabetes, tracking your blood sugar alongside your urinary frequency provides valuable context