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Obesity Research A phase 2 randomized trial published in NEJM included 338 adults

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if you break an extended fast with a heavy, high-fat, or acidic meal, the combination frequently produces: Nausea Fullness Belching Reflux That pattern is emotionally draining because it forces constant tradeoffs between weight-management goals and comfort, and it pushes many people into guessing rather than measuring what actually sets off symptoms

Lilly's triple agonist retatrutide delivered weight loss of up to 28.7% in adults with obesity