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SGLT-1 is a low-capacity, high-affinity sodium-glucose transporter found primarily in the gastrointestinal tract, but it is also found in the S3 segment of the proximal tubule within the nephron

Traditionally available only as injections, GLP1 receptor agonists have shown impressive results in lowering blood glucose, aiding in weight loss, and protecting the heart

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Therefore, further long-term studies with cardiovascular end points are warranted

Ambery P, Parker VE, Stumvoll M et al (2018) MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study