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Non-Alcoholic Fatty Liver Disease: From Pathogenesis to Clinical Impact

Knop: Back in 2009, in my effort to better understand how the gut hormone glucagon-like peptide 1 (GLP-1) is secreted, I read TGR5-mediated bile acid sensing controls glucose homeostasis (Thomas, et al.), which described how bile acids may stimulate the secretion of this glucose-lowering and satiety-promoting hormone

doi: 10.1053/j.gastro.2011.12.053 232 RaybouldH

During a 40-week study 18 , people receiving 1 milligram of Ozempic lost an average of 13 lbs while those receiving a 2-milligram dose lost an average of 15 pounds

GCGR, glucagon receptor