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When to seek medical attention: Severe, persistent abdominal pain radiating to the back (possible pancreatitis) Persistent vomiting preventing adequate hydration Signs of dehydration: decreased urination, dizziness, extreme thirst Severe diarrhea lasting more than 48 hours Jaundice or dark urine (suggesting biliary obstruction, which remains possible despite cholecystectomy) Patients should be reassured that most gastrointestinal side effects improve significantly within 4-8 weeks of reaching a stable dose

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