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Repeated measurements of endocrine markers were analyzed with linear mixed-effects (LME) models, having drug condition (placebo, oral cannabis, smoked cannabis, and vaporized cannabis), session number (1, 2, 3, and 4), blood sampling time-point (T1, T2, T3, and T4), and drug time-point interaction as fixed effects, individual subjects as a random effect (random intercept and slope), and each hormone as the outcome

Int J Med Sci (2013) 10(7):796803

Its likely there will be several populations who can benefit from the drug once approved

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Estrogen prevents neuroprotection by caffeine in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of parkinsons disease