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These benefits include reducing neuroinflammation, improving neuronal energy homeostasis, and limiting neurodegenerative progression ( Potential mechanisms by which GLP-1RAs enhance cognition in T2DM patients include attenuation of oxidative stress, suppression of neuroinflammation, inhibition of apoptosis, reduction or prevention of A accumulation, and mitigation of tau aggregation ( These pharmacological advances have reshaped the management of metabolic diseases, improving glycemic control, weight reduction, and cardiovascular outcomes

Diabetes 63 , 33463358 (2014)

Secondary endpoints for both medications included changes in waist circumference, body mass index, and other metabolic markers

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Since then, however, the pricing environment in the US market has become far more hostile, with potentially significant global implications for drug approval and launch strategies