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Contraindications to taking semaglutide include the following: A personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 Known hypersensitivity to semaglutide or any of the medication components Semaglutide Warnings Semaglutide can cause serious health problems, particularly in people who are predisposed to these conditions

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Last reviewed: July 10, 2026 Last updated: July 10, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

With guidance from a healthcare provider or registered dietitian, some people use targeted nutritional supplements as part of this monitoring process

The safest approach is increasing potassium through food sources first, then supplementing conservatively if needed, always under medical guidance