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Glucagon-like peptide-1 (GLP-1), immediately prior to reperfusion, decreases neutrophil activation and reduces myocardial infarct size in rodents

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While their glycemic, weight-lowering, and cardiovascular benefits are well established through randomized trials and meta-analyses, concerns remain regarding their safety and tolerability across diverse populations and clinical settings

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Similarly, in the perfused rat pancreas, GLP-1 (25 nmol/l) mediated a slight insulin secretion at basal glucose concentrations (2.8 mmol/l) but when glucose concentrations were raised to 5 mmol/l, a strong GLP-1-mediated stimulation of insulin secretion, which exceeded the effects observed with glucose alone, was observed [28]
