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A 2-year carcinogenicity study was conducted with tirzepatide in male and female rats at doses of 0.15, 0.50, and 1.5 mg/kg (0.1-, 0.4-, and 1-fold the MRHD of 15 mg once weekly based on AUC) administered by subcutaneous injection twice weekly
Many say this was an unfair comparison and if the full 2.4 mg dose of semaglutide was used the difference may have been smaller or nonexistent

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