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10.1016/j.physbeh.2012.03.014 18 FarokhniaM.BrowningB

Studies have found that GLP-1R is widely distributed on pancreatic and other tissues and has multiple biological effects, such as reducing neuroinflammation, promoting nerve growth, improving heart function, suppressing appetite, delaying gastric emptying, regulating blood lipid metabolism and reducing fat deposition

This weight loss effect is primarily due to a reduction in food intake resulting from GLP-1RA acting on several regions of the brain [[10], [11], [12], [13], [14]]

While they have been praised for their effectiveness, GLP-1 receptor agonists come with serious health risks that were not fully disclosed by their manufacturers