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It was found that GLP-1 affects the immune response and induces M2 macrophage polarization via STAT3 activation signalizing

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Psychological Impact of Weight Gain and Diet Fatigue Years of failed attempts often erode confidence and contribute to shame, anxiety, and social isolation

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What You May Notice Over Time Weeks 1 to 2: You may start to feel full sooner and think about food less often Weeks 2 to 4: Cravings may feel less intense and meals may start to feel easier to manage Weeks 4 to 8: Some people begin to notice gradual weight loss, along with steadier energy or better control of eating After 8 weeks: Weight loss may become more noticeable as healthy habits and treatment start working together