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P., Colditz, G

68 Since administered GLP-1 does not produce hypoglycemia, these clinical findings have led to the use of GLP-1 receptor (GLP-1R) agonists as a new class of blood glucose-lowering agents for use in the treatment of type 2 diabetes mellitus (T2DM)

The drug has been studied in human trials, including a Phase 2 trial published in The Lancet in 2008 and a Phase 3 trial in 372 patients in Mexico, but a dedicated cardiovascular outcomes trial that US and EU regulators would expect has not been run

For patients who have struggled with standard titration schedules or abandoned previous attempts due to intolerable side effects, this protocol offers an alternative path forward