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Regul Pept 111: 137-144, 2003

It critically examines traditional treatments, noting their limitations in sustaining weight loss or reducing complications

Part of the GLP-1RA (Liraglutide, Semiglutide) has been verified to be efficacious in the treatment of fatty liver and is employed in the management of T2DM complicated with nonalcoholic fatty liver disease, primarily by ameliorating metabolic dysfunction, insulin resistance, and lipotoxicity of the organs related to its pathogenesis (61), decelerating the fibrosis process and reducing the liver fat content

Compensatory changes in the levels of weight-regulating hormones such as leptin, ghrelin, peptide YY, and gastric inhibitory peptide can counteract diet-induced weight loss, highlighting the difficulty in maintaining weight loss through diet alone [11]

Growth hormone stimulates proteinsynthesis and inhibits muscle breakdown, which is particularly relevant whenthe body is losing weight and might otherwise catabolize lean tissue forenergy