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Even with insurance, tirzepatide copays can exceed $1,500 per month because Aetna and other insurers often classify it as a specialty tier drug
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However, if youre taking other diabetes medications, particularly insulin or sulfonylureas, the risk increases
doi: 10.1111/dom.16366
Consistent with this, GLP-1, exendin-4, and the DPP-4 inhibitor sitagliptin reduced proximal tubular sodium reabsorption in rats [660,761,769,770] and humans [663]
