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Another significant difference between both drugs is the side effects

Others feel less appetite control initially because 2.5 mg provides less GLP-1 activation than their previous semaglutide dose

Hair loss associated with tirzepatide treatment is most commonly attributed to telogen effluvium , a form of temporary hair shedding triggered by physiological stress rather than a direct pharmacological effect of the medication itself

The metabolic clearance occurs by proteolytic cleavage of the tirzepatide peptide backbone, -oxidation of the C20 fatty diacid moiety, and by amide hydrolysis

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