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This distension can trigger accelerated lower intestinal transit as your gut tries to make room, resulting in loose stools

They can interact with: Insulin or sulfonylureas: Risk of low blood sugar

In addition to the higher -helix propensity, the more pronounced amphiphilic nature of exendin-4 enables stronger polar and hydrophobic interactions with the ECD of GLP-1R via opposite sides of the -helix than GLP-1 (vide infra)

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