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The exciting beyond obesity frontier for GLP-1 drugs is their potential to treat conditions where inflammation, or other non-obesity factors, are the primary cause

Insulin secretion and GCG suppression are both controlled by it in the pancreas

By decreasing apoptosis, promoting mitogenesis, and increasing autophagy flux, exendin-4 and DA-CH5 have been demonstrated to protect SH-SY5Y cells against the cytotoxicity of 6-hydroxydopamine (6-OHDA)

These pathways include the cyclic AMP-protein kinase A (cAMP-PKA) pathway, phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling, and nuclear factor kappa B (NF-B)-mediated cascades, which regulate cell proliferation, apoptosis, and migration