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The relative risk of symptomatic cholelithiasis was 1.6, 0.9, and 1.4 in liraglutide, dulaglutide, and semaglutide with number needed to harm of 3.14, 16.67, and 5.56, respectively

Triagonists (for example GLP-1/GIP/glucagon) are currently in pre-clinical or early clinical development

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While positive for consumers, it places significant financial pressure on an already brittle healthcare and Medicare ecosystem

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