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Peptides are small chains of amino acids that can mimic natural hormones in the body

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Variants in GLP1R (the GLP-1 receptor itself), GIPR (the GIP receptor that tirzepatide also activates), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with measurably different response patterns to semaglutide and tirzepatide