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subsequently confirmed this association in a large multicenter database study of 37.1 million adults, but the incidence was low at 14.5 per 100,000 person-years among semaglutide users, and there was only a modest increase in risk attributable to semaglutide (90)

Across the 52 weeks of ATTAIN-MAINTAIN, participants treated with orforglipron gained an average of 5 kg (11 lbs) in the tirzpatide group and an average of 1 kg (2.2 lbs) in the semaglutide group

Dual GLP-1 RA and glucagon agonists as well as Triple GLP-1/GIP/glucagon RA are still ongoing clinical evaluations but have shown significant reduction in HbA1c levels and weight management

Beejal Vyas-Price of McCann Healthcare, Australia

One risk mitigation strategy is for elective patients to have a clear fluid diet for the day before surgery