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Patients on retatrutide frequently describe feeling satiated with smaller amounts of food, contributing to their reduced caloric intake

If patients do not tolerate the 25 mg once daily maintenance dosage, consider switching to WEGOVY injection 1.7 mg once weekly [see Dosage and Administration (2.5)]

1e,f and Extended Data Fig

141 They remain in the body, interacting with GLP-1 receptors in various organs, which could lead to DDIs through mechanisms of action such as slowing gastric emptying, reducing fat mass and inflammation, and increasing glomerular filtration rate (GFR) and renal plasma flow, consequently altering the pharmacokinetics of the victim drug (Figure 3)

Two other generic Victoza options are being developed and could launch in December 2024