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Medically supervised GLP-1 weight loss program with tirzepatide and semaglutide.

After adjustment for sex, BMI, hsCRP, and sCD163, semaglutide significantly decreased epigenetic aging: PCGrimAge (-3.1 years, P = 0.007), GrimAge V1 (-1.4 years, P = 0.02), GrimAge V2 (-2.3 years, P = 0.009), PhenoAge (-4.9 years, P = 0.004), and DunedinPACE (-0.09 units, 9 % slower pace, P = 0.01)

Combining GLP-1 therapy with HRT during menopause requires careful medical oversight