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This divergent evidence may be due to the different experimental conditions of the studies

Results of cardiovascular safety studies have not shown any indication of cardiovascular harm, with possible suggestion of cardiovascular benefit

A recent network meta-analysis suggested that GLP-1R agonists were associated with significantly greater activity in decreasing liver fat content and improving cardiometabolic risk parameters in overweight or obese patients with NAFLD vs

Lixisenatide The FDA approved lixisenatide, marketed as Adlyxin, in 2016 for Type 2 diabetes

Hence, incretin-based therapies represent a strategy for the treatment of T2DM