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Additionally, eliminating excess weight can decrease the strain on joints and may alleviate certain obesity-related health conditions

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Conclusion In this real-world study, adults with obesity or overweight treated with semaglutide 2.4 mg had greater reductions in weight and improvements in cardiometabolic risk factors compared with patients not treated with OM at 12 months

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Evaluating these surrogate endpoints can help physicians draw clinically important conclusions about a therapeutic intervention because of their proven association with these outcomes

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10.1111/j.1464-5491.2009.02790.x 94 OkaJ

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Rapid Weight Loss: While semaglutide is effective for weight loss, rapid shedding of pounds can lead to muscle loss, including the muscles that help regulate blood pressure, increasing fainting risk

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