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All tirzepatide doses were superior to all comparators in terms of reducing body weight

Cummings JL, Atri A, Sano M, et al

The inclusion in our network analysis of the AMPLITUDE-O and EMPEROR-P data have modified the conclusions of the most recent similar analysis [15] indicating that SGLT-2 inhibitors increased the risk of stroke as compared with GLP-1RA and that GLP-1RA are superior to DPP-4 inhibitors as for nonfatal MI

Other proposed mechanisms underlying GLP-1 receptor agonisms role in facilitating natriuresis include reduction of RAAS activity through central nervous system signaling and alteration of ANP concentrations

But doctors caution that enthusiasm has outpaced realism