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Description
The concept of incretin effect was first proposed by Creutzfeldt in the 1970s (1, 2), based on the early observations that insulin secretion was two to three times higher after oral glucose intake than that after an isocaloric intravenous glucose administration (35)
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cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells
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