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Where Is Tirzepatide Used

Beyond their metabolic effects, GLP-1 RAs have demonstrated cardiovascular and renal benefits in large outcome trials, including reductions in major adverse cardiovascular events (MACE) and attenuation of albuminuria progression ( Table 1 , renal eligibility criteria across landmark GLP-1 RA cardiovascular and kidney outcome trials consistently excluded dialysis-dependent patients, resulting in a persistent lack of randomized evidence in this high-risk population

Scheme 28

Harvard Medical School

to reduce excess body weight and maintain weight reduction long term in: o Adults and pediatric patients aged 12 years and older with obesity o Adults with overweight in the presence of at least one weight-related comorbid condition For more on the use of semaglutide injection (Wegovy ) to treat obesity and overweight, please see the following article on this website: Semaglutide injection (Wegovy) for weight loss in obesity and overweight Mechanism of Action/ Pharmacodynamics Semaglutide belongs to a group of medications called glucagon-like peptide-1 (GLP-1) agonists