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Phase 3 data on retatrutide (triple GLP-1/GIP/glucagon agonist) showing nearly 29% weight loss, the pending approval of CagriSema (GLP-1/amylin combination), and the arrival of oral non-peptide GLP-1 agonists like orforglipron all suggest we are at the start of a metabolic therapeutics renaissance

doi: 10.1161/HYPERTENSIONAHA.119.14400 81 KamiyamaMUrushiharaMMorikawaTKonishiYImanishiMNishiyamaAet al

Studies in rats have identified GLP-1R expression in both the nodose ganglion (162) and vagal nerve terminals innervating the portal vein (163), and GLP-1 has been shown to increase impulse generation in both gastric and hepatic vagal afferent fibers (164, 165)

Karagiannis T, et al

Clinical Evidence and FDA Approval Status for Sleep Apnea Medication Looking into treatments for moderate sleep apnea, we must check the clinical evidence and FDA approval of medications