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The average weight loss with GLP-1 is 1.5-2lbs per week, and can be accelerated when coupled with the correct nutritional diet

Consequently, a 30-pound weight loss could reduce knee loading by 90-120 pounds with each step, representing substantial mechanical relief

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A medications value depends on clinical evidence, FDA approval status, safety, tolerability, medical history, side-effect risk, and long-term outcomes

Combination therapy with glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors in older patients with type 2 diabetes: A real-world evidence study