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Medication remains effective unless storage conditions are poor or it has expired rather than due to the body building tolerance

Lower exposure can reduce appetite control and lead to inconsistent response

Exendin-4 Ex-4 has been shown to enhance pancreatic beta-cell marker expression (pancreatic and duodenal homeobox 1 ( PDX-1 ), NK2 homeobox 2 ( NKX2.2) , ISL LIM homeobox 1 (I SL-1 ) and v-Maf musculoaponeurotic fibrosarcoma oncogene homolog A ( MAFA)) [35,36,37]

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