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The main surgical procedures are divided into restrictive ones, such as adjustable gastric banding (AGB) that uses an adjustable silicone ring to reduce gastric capacity, vertical sleeve gastrectomy (VSG), which involves removing most of the stomach, reducing it to a vertical gastric sleeve, and mixed restrictive-malabsorptive procedures such as Roux-en-Y gastric bypass (RYGB), in which a small gastric pouch is created and anastomosed to a jejunal loop, and biliopancreatic diversion (BPD) which involves resecting the distal stomach anastomosed to the final segment of the small intestine [84]

Tirzepatide is also a glucose-dependent insulinotropic polypeptide (GIP) agonist

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JAMA 315, 898907
