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Insulin resistance and chronic hyperglycemia cause a cascade of pathological events in the brain, including neuroinflammation, impaired neurotransmitter systems and energy metabolism, oxidative stress, and vascular pathologies that ultimately lead to neurodegeneration, loss of synaptic plasticity, brain aging, cognitive impairment, and dementia

Why the caveats: Most human data is observational, not randomized controlled trials designed to prove prevents dementia. So far, we cannot definitively say GLP-1 RAs prevent Alzheimers

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However, the incidence of CRC was not significantly associated with GLP-1 RA use compared with other drugs (OR, 1.73

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