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Exploratory analyses found no meaningful differences in effect between participants with baseline BPs above versus below the cohort median baseline BP or between those with controlled versus uncontrolled hypertension

A systematic review comparing these medications found that retatrutide (12 mg) achieved 22% weight loss from baseline, compared to 18% for tirzepatide and 14% for semaglutide

3 Reduced risk for breast cancer was similar in women both with and without diabetes and among both Black and White women

However, doctors prescribe weight loss medications (like GLP-1s) because losing weight is the most effective way to treat the underlying cause

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